Orlistat Inhibits Dietary Cholesterol Absorption

تاریخ : ۱۳۹۳/۰۴/۳۰ / تعداد بازدید : ۳۹۵

Abstract

Objective

Orlistat decreases the absorption of dietary triglycerides by inhibiting intestinal lipases. Orlistat therapy is associated with a greater decline in plasma low-density lipoprotein-cholesterol concentrations than that expected from weight loss alone. Therefore, we evaluated the effect of orlistat treatment on dietary cholesterol absorption as a possible mechanism for the independent effect of orlistat on plasma cholesterol concentration.

Research Methods and Procedures

Cholesterol absorption from a standardized meal, containing 72 mg of cholesterol, was determined in 18 subjects with class II abdominal obesity (BMI, 35.0 to 39.9 kg/m2) by simultaneous administration of intravenous ([2H6] cholesterol) and oral ([2H5] cholesterol) cholesterol tracers. In protocol 1 (n 5 9), cholesterol absorption was determined on two different occasions, 10 to 20 days apart, to assess the reproducibility of the tracer method. In protocol 2 (n 5 9), cholesterol absorption was determined with and without orlistat therapy in a prospective, randomized, crossover design to assess the effect of orlistat on cholesterol absorption.

Results

In protocol 1, cholesterol absorption from the test meal was the same on both occasions (5365% and 5165%). In protocol 2, orlistat treatment caused a 25% reduction in cholesterol absorption, from 59 6 6% to 44 6 5% (p , 0.01).

Discussion

These data demonstrate that orlistat inhibits dietary cholesterol absorption, which may have beneficial effects on lipoprotein metabolism in obese subjects that are independent of weight loss itself.

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Orlistat Inhibits Dietary Cholesterol Absorption

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